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COMET™

All-in-one staining and imaging platform for hyper-plex immunofluorescence.

A fully-automated instrument that works with off-the-shelf,
label-free primary antibodies.

With COMET™, it is possible to simultaneously detect and visualize
up to 40 markers on the same tissue sample, requiring
under 30 minutes for every two markers.

COMET™ will be for Research Use Only.
Pilot units soon available through Priority Access Program.

Check out
our features

Experience a fully automated workflow

COMET™ integrates the staining and imaging steps to avoid instrument manipulation during the entire process.

Use your preferred antibodies

COMET™ is designed to satisfy researchers' flexibility needs and works with off-the-shelf, label-free antibodies. As simple as that.

Increase your hyperplex throughput

With a capacity for 4 slides, and average turnaround times of 30 minutes every 2 markers, COMET™ is a unique mid-throughput instrument powered by the speed of microfluidics.

Markers (tap to toggle on and off)


24 markers on tonsil tissue. Total experiment time: 5h

PATENTED TECHNOLOGY

The key innovation lies in Lunaphore’s unique microfluidic technology – called Fast Fluidic Exchange (FFeX) – where a chip clamped over a standard histological glass slide forms a closed chamber of reaction over the tissue. This allows fast and uniform delivery of reagents, greatly reducing the incubation times.

The chip’s imaging window allows to integrate staining and imaging, avoiding sample manipulation in between steps.

Learn more about the technology

COMET Platform

Click on the buttons to read the description.

COMET
  • REAGENTS MODULE

    Reagents and buffers are loaded in small and large volume reservoirs respectively and delivered to the sample through microfluidic channels.

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  • MICROSCOPE

    Compact fluorescent microscope. Images through the chip.

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  • STAINING MODULE

    Rotary stage where up to four slides are inserted and clamped against the Imaging Chip. Its unique design allows for staining and imaging parallelization.

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How it works

MULTIPLEXED IMMUNOFLUORESCENCE

Our sequential immunofluorescence assay consists of repeated cycles of staining, imaging, and elution.

  • Controlled by an automated protocol, primary and secondary antibodies are delivered onto the tissue and incubated.
  • The integrated microscope then acquires the image through the glass window of the chip.
  • The signal is erased by removing the primary-secondary antibody complex with a dedicated elution buffer and a non-destructive heating-cooling cycle.

The acquired images are later automatically stitched and stacked together by the instrument software.

About the application

Request more information

If you're interested in the COMET™ Early Access Program or you would like to receive more detailed information about COMET™ and its features, please fill out the form below.

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